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1

ChemInform Abstract: Stereospecific Synthesis of 7-Deoxy-6-hydroxy Paclitaxel.

Mark D. Wittman, Thomas J. Alstadt, John F. Kadow, Dolatrai M. Vyas, Kathy Johnson, Craig Fairchild, Byron Long

Journal:

Year:

1999

File:

PDF, 24 KB

1999

2

ChemInform Abstract: Synthesis and Antitumor Activity of Novel Paclitaxel—Chlorambucil Hybrids.

Mark D. Wittman, John F. Kadow, Dolatrai M. Vyas, Francis L. Lee, William C. Rose, Byron H. Long, Craig Fairchild, Kathy Johnston

Journal:

Year:

2001

File:

PDF, 28 KB

2001

3

ChemInform Abstract: Synthesis of 7β-Sulfur Analogues of Paclitaxel Utilizing a Novel Epimerization of the 7α-Thiol Group.

Harold Mastalerz, Guifen Zhang, John Kadow, Craig Fairchild, Byron Long, Dolatrai M. Vyas

Journal:

Year:

2001

File:

PDF, 34 KB

2001

4

ChemInform Abstract: Oxime Derivatives of Sordaricin as Potent Antifungal Agents.

Michael H. Serrano-Wu, Denis R. St. Laurent, Charles E. Mazzucco, Terry M. Stickle, John F. Barrett, Dolatrai M. Vyas, Balu N. Balasubramanian

Journal:

Year:

2002

File:

PDF, 27 KB

2002

5

Synthesis and Biological Activity of Macrocyclic Taxane Analogues.

James G. Tarrant, Donald Cook, Craig Fairchild, John F. Kadow, Byron H. Long, William C. Rose, Dolatrai Vyas

Journal:

Year:

2004

File:

PDF, 20 KB

2004

6

ChemInform Abstract: Nucleophilic Capture of the Imino-Quinone Methide Type Intermediates Generated from 2-Aminothiazol-5-yl Carbinols.

Mark G. Saulnier, Marco Dodier, David B. Frennesson, David R. Langley, Dolatrai M. Vyas

Journal:

Year:

2010

File:

PDF, 56 KB

2010

7

Editorial

Dolatrai M. Vyas, Terrence W. Doyle

Journal:

Drug Development Research

Year:

1995

Language:

english

File:

PDF, 158 KB

english, 1995

8

Carbon-13 nuclear magnetic resonance-spectral study of branched-chain and 3-gem-di-C-substituted aldohexofuranoid derivatives

Olivier R. Martin, Robert C. Nabinger, Yousif Ali, Dolatrai M. Vyas, Walter A. Szarek

Journal:

Carbohydrate Research

Year:

1983

Language:

english

File:

PDF, 306 KB

english, 1983

9

Heck reactions in solid phase synthesis

Kuo-Long Yu, Milind S. Deshpande, Dolatrai M. Vyas

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 236 KB

english, 1994

10

Synthesis of intermediates for the preparation of core analogs of esperamicin

Harold Mastalerz, Terrence Doyle, John Kadow, Kinwa Leung, Dolatrai Vyas

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 211 KB

english, 1995

11

Diastereoselective addition of Grignard reagents to azetidine-2,3-dione: Synthesis of novel Taxol® analogues

Joydeep Kant, Wendy S. Schwartz, Craig Fairchild, Qi Gao, Stella Huang, Byron H. Long, John F. Kadow, David R. Langley, Vittorio Farina, Dolatrai Vyas

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 223 KB

english, 1996

12

Structure-activity relationships of taxol®: synthesis and biological evaluation of C2 taxol analogs

Shu-Hui Chen, Vittorio Farina, Jian-Mei Wei, Bryon Long, Craig Fairchild, Stephen W. Mamber, John F. Kadow, Dolatrai Vyas, Terrence W. Doyle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 278 KB

english, 1994

13

The synthesis and biological activity of enediyne minor groove binding hybrids

Mark D. Wittman, John F. Kadow, David R. Langley, Dolatrai M. Vyas, William C. Rose, Wyle Solomon, Nada Zein

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 173 KB

english, 1995

14

Synthesis and biological activity of macrocyclic taxane analogues

James G. Tarrant, Donald Cook, Craig Fairchild, John F. Kadow, Byron H. Long, William C. Rose, Dolatrai Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 269 KB

english, 2004

15

New dual inhibitors of EGFR and HER2 protein tyrosine kinases

Brian E. Fink, Gregory D. Vite, Harold Mastalerz, John F. Kadow, Soong-Hoon Kim, Kenneth J. Leavitt, Karen Du, Donald Crews, Toomas Mitt, Tai W. Wong, John T. Hunt, Dolatrai M. Vyas, John S. Tokarski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 176 KB

english, 2005

16

Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile

Upender Velaparthi, Peiying Liu, Balu Balasubramanian, Joan Carboni, Ricardo Attar, Marco Gottardis, Aixin Li, Ann Greer, Mary Zoeckler, Mark D. Wittman, Dolatrai Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 153 KB

english, 2007

17

Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase

Anthony J. Sampognaro, Mark D. Wittman, Joan M. Carboni, Chiehying Chang, Ann F. Greer, Warren W. Hurlburt, John S. Sack, Dolatrai M. Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 529 KB

english, 2010

18

Synthesis of gem-di-C-substituted derivatives of carbohydrates by way of nucleophilic-addition reactions of aldohexofuranoid 3-C-methylene derivatives

Yousif Ali, Dolatrai M. Vyas, Robert C. Nabinger, Walter A. Szarek

Journal:

Carbohydrate Research

Year:

1982

Language:

english

File:

PDF, 822 KB

english, 1982

19

Carbon-13 nuclear magnetic resonance spectra of carbohydrate oxirane derivatives

Soo Kim Kwan, Dolatrai M. Vyas, Walter A. Szarek

Journal:

Carbohydrate Research

Year:

1979

Language:

english

File:

PDF, 662 KB

english, 1979

20

Facile Synthesis of a Simplified Bicyclo[7.3.1] Esperamicin-Calicheamicin Enediyne Core

John F. Kadow, Donald J. Cook, Terrence W. Doyle, David R. Langley, Kahnie M. Pham, Dolatrai M. Vyas, Mark D. Wittman

Journal:

Year:

1994

Language:

english

File:

PDF, 1.38 MB

english, 1994

21

Stereospecific synthesis of the major human metabolite of paclitaxel

Mark D Wittman, John F Kadow, Dolatrai M Vyas

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 124 KB

english, 2000

22

Conformational analysis of nucleoside analogs of six-membered heterocycles containing oxygen and/or sulfur

Walter A. Szarek, Dolatrai M. Vyas, Barbara Achmatowicz

Journal:

Tetrahedron Letters

Year:

1975

Language:

english

File:

PDF, 211 KB

english, 1975

23

A chemoselective approach to functionalize the C-10 position of 10-deacetylbaccatin III. Synthesis and biological properties of novel C-10 Taxol® analogues

Joydeep Kant, Wendy S. O'Keeffe, Shu-Hui Chen, Vittorio Farina, Craig Fairchild, Kathy Johnston, John F. Kadow, Byron H. Long, Dolatrai Vyas

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 356 KB

english, 1994

24

Conjugate addition-aldol approach to the simple bicyclic-diynene core structure found in the esperamicins and calicheamicins

John F. Kadow, Min Min Tun, Dolatrai M. Vyas, Mark D. Wittman, Terrence W. Doyle

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 281 KB

english, 1992

25

A facile synthesis of 7,10-dideoxy taxol and 7-epi-10-deoxy taxol

Shu-Hui Chen, Jian-Mei Wei, Dolatrai M. Vyas, Terrence W. Doyle, Vittorio Farina

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 219 KB

english, 1993

26

Synthesis of an esperamicin core analog with an epoxide trigger

Harold Mastalerz, Terrence W Doyle, John F Kadow, Dolatrai M Vyas

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 198 KB

english, 1996

27

Synthesis of a hybrid analog of the esperamicin and dynemicin cores

Harold Mastalerz, Terrence W Doyle, John F Kadow, Dolatrai M Vyas

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 223 KB

english, 1996

28

Crystallographic determination of the stereochemistry of C-6,7 epoxy paclitaxel

Thomas J. Altstadt, Qi Gao, Mark D. Wittman, John F. Kadow, Dolatrai M. Vyas

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 156 KB

english, 1998

29

Stereospecific synthesis of 7-deoxy-6-hydroxy paclitaxel

Mark D. Wittman, Thomas J. Alstadt, John F. Kadow, Dolatrai M. Vyas, Kathy Johnson, Craig Fairchild, Byron Long

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 193 KB

english, 1999

30

Structure–activity relationships study at the 3′-N position of paclitaxel. part 2: synthesis and biological evaluation of 3′-N-thiourea- and 3′-N-thiocarbamate-bearing paclitaxel analogues

May Xue, Byron H Long, Craig Fairchild, Kathy Johnston, William C Rose, John F Kadow, Dolatrai M Vyas, Shu-Hui Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 190 KB

english, 2000

31

Synthesis and biological activity of 3′,4′,5′-trihydroxy etoposide

Mark G. Saulnier, Karen L. LeBoulluec, Danny P.C. McGee, Byron H. Long, Alfred R. Crosswell, Dolatrai M. Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 379 KB

english, 1993

32

Novel water soluble phosphate prodrugs of taxol® possessing in vivo antitumor activity

Yasutsugu Ueda, Amarendra B. Mikkilineni, Jay O. Knipe, William C. Rose, Anna Maria Casazza, Dolatrai M. Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 453 KB

english, 1993

33

Taxol® structure-activity relationships: synthesis and biological evaluation of taxol analogs modified at C-7

Shu-Hui Chen, Joydeep Kant, Stephen W. Mamber, Gregory P. Roth, Jian-Mei Wei, Dan Marshall, Dolatrai M. Vyas, Vittorio Farina, Annamaria Casazza, Byron H. Long, William C. Rose, Kathy Johnston, Craig

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 433 KB

english, 1994

34

Synthesis of biological evaluation of 4′-deshydroxy-4′-methyl etoposide and teniposide analogs

Mark G. Saulnier, Karen L. LeBoulleuc, Byron H. Long, Dolatrai M. Vyas, Alfred R. Crosswell, Terrence W. Doyle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 425 KB

english, 1992

35

Synthesis and antitumor evaluation of water soluble taxol phosphates

Dolatrai M. Vyas, Henry Wong, Alfred R. Crosswell, Anna Maria Casazza, Jay O. Knipe, Stephen W. Mamber, Terrence W. Doyle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 272 KB

english, 1993

36

Protein damage caused by a synthetic enediyne core

Nada Zein, Wyle Solomon, Anna Maria Casazza, John F. Kadow, Bala S. Krishnan, Min Min Tun, Dolatrai M. Vyas, Terrence W. Doyle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 432 KB

english, 1993

37

Etoposide(VP16): Chemical reactivity of etoposide ortho-quinone with amines and thiols

Dolatrai M. Vyas, John F. Kadow, Karen L. LeBoulluec, Mark G. Saulnier, Terrence W. Doyle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 389 KB

english, 1992

38

Synthesis and antileukemic activity of etoposide a-ring analogs

John F. Kadow, Min Min Tun, Alfred R. Crosswell, William C. Rose, Dolatrai M. Vyas, Terrence W. Doyle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 371 KB

english, 1992

39

Synthesis and antitumor activity of novel paclitaxel–chlorambucil hybrids

Mark D. Wittman, John F. Kadow, Dolatrai M. Vyas, Francis L. Lee, William C. Rose, Byron H. Long, Craig Fairchild, Kathy Johnston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 194 KB

english, 2001

40

Synthesis of metabolically blocked paclitaxel analogues

Mark D. Wittman, Thomas J. Altstadt, Craig Fairchild, Stephen Hansel, Kathy Johnston, John F. Kadow, Byron H. Long, William C. Rose, Dolatrai M. Vyas, Mu-Jen Wu, Mary E. Zoeckler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 108 KB

english, 2001

41

Synthesis of etoposide phosphate, BMY-40481: A water-soluble clinically active prodrug of etoposide

Mark G. Saulnier, David R. Langley, John F. Kadow, Peter D. Senter, Jay O Knipe, Min Min Tun, Dolatrai M. Vyas, Terrence W. Doyle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 368 KB

english, 1994

42

The effect of propargylic substitution on the activation and aromatization of enediynes

Mark D. Wittman, John F. Kadow, Kahnie Pham, Leung Kinwa, Harold A. Mastalerz, Dolatrai M. Vyas, William C. Rose, Wyle Solomon, Nada Zein

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 289 KB

english, 1994

43

Studies toward structure-activity relationships of taxol®: synthesis and cytotoxicity of taxol® analogues with C-2′ modified phenylisoserine side chains

Joydeep Kant, Stella Huang, Henry Wong, Craig Fairchild, Dolatrai Vyas, Vittorio Farina

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 305 KB

english, 1993

44

Core-modified sordaricin derivatives: Synthesis and antifungal activity

Alicia Regueiro-Ren, Tina M. Carroll, Yijun Chen, James A. Matson, Stella Huang, Charles E. Mazzucco, Terry M. Stickle, Dolatrai M. Vyas, Balu N. Balasubramanian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 100 KB

english, 2002

45

Sordaricin antifungal agents

Claude A Quesnelle, Patrice Gill, Marco Dodier, Denis St. Laurent, Michael Serrano-Wu, Anne Marinier, Alain Martel, Charles E Mazzucco, Terry M Stickle, John F Barrett, Dolatrai M Vyas, Balu N Balasub

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 245 KB

english, 2003

46

Structure-activity relationships study at the 3′-N position of paclitaxel-part 1: Synthesis and biological evaluation of the 3′-(t)-butylaminocarbonyloxy bearing paclitaxel analogs

Shu-Hui Chen, May Xue, Stella Huang, Byron H Long, Craig A Fairchild, William C Rose, John F Kadow, Dolatrai Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 256 KB

english, 1997

47

Synthesis of a paclitaxel isomer: C-2-acetoxy-C-4-benzoate paclitaxel

Shu-Hui Chen, Vittorio Farina, Dolatrai M. Vyas, Terrence W. Doyle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 225 KB

english, 1998

48

Novel, water-soluble phosphate derivatives of 2′-ethoxy carbonylpaclitaxel as potential prodrugs of paclitaxel: Synthesis and antitumor evaluation

Yasutsugu Ueda, John D. Matiskella, Amarendra B. Mikkilineni, Vittorio Farina, Jay O. Knipe, William C. Rose, Anna Maria Casazza, Dolatrai M. Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 308 KB

english, 1995

49

Novel C-4 paclitaxel (Taxol®) analogs: potent antitumor agents

Shu-Hui Chen, Jian-Mei Wei, Byron H. Long, Craig A. Fairchild, Joan Carboni, Steven W. Mamber, William C. Rose, Kathy Johnston, Anna M. Casazza, John F. Kadow, Vittorio Farina, Dolatrai M. Vyas, Terre

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 394 KB

english, 1995

50

Synthesis and antitumor evaluation of paclitaxel phosphonooxymethyl ethers: a novel class of water soluble paclitaxel pro-drugs

Jerzy Golik, Henry S.L. Wong, Shu Hui Chen, Terrence W. Doyle, J.J. Kim Wright, Jay Knipe, William C. Rose, Anna Maria Casazza, Dolatrai.M. Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 317 KB

english, 1996

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